A design optimization study on synthesized nanocrystalline cellulose, evaluation and surface modification as a potential biomaterial for prospective biomedical applications

Fahanwi Asabuwa Ngwabebhoh; Ahmet Erdem; Ufuk Yildiz

doi:10.1016/j.ijbiomac.2018.03.155

A design optimization study on synthesized nanocrystalline cellulose, evaluation and surface modification as a potential biomaterial for prospective biomedical applications

Int J Biol Macromol. 2018 Jul 15:114:536-546. doi: 10.1016/j.ijbiomac.2018.03.155. Epub 2018 Mar 27.

Authors

Fahanwi Asabuwa Ngwabebhoh¹, Ahmet Erdem², Ufuk Yildiz²

Affiliations

¹ Department of Chemistry, Kocaeli University, 41380 Kocaeli, Turkey. Electronic address: asabuwa.fahanwi@kocaeli.edu.tr.
² Department of Chemistry, Kocaeli University, 41380 Kocaeli, Turkey.

PMID: 29601877
DOI: 10.1016/j.ijbiomac.2018.03.155

Abstract

In the present study, nanocrystalline cellulose (NCC) was prepared via acid hydrolysis and synthesis parameters were optimized via response surface modelling with a determined maximum NCC yield of 43.8%. The optimized NCC sample was subsequently surface modified via epichlorohydrin-mediated amination forming aminated nanocrystalline cellulose (A-NCC) with an amine content calculated as 1500μmol/g. The average particle size and zeta potential were determined 100nm and 325nm for NCC and A-NCC, respectively. Structural properties were analyzed by FTIR, TEM and XRD techniques. The obtained A-NCC as final product depicted a pKa value of 10.86±0.07 demonstrating favourable protonation of amine groups at physiological pH allowing the material to be suitable for prospective application in drug delivery and tissue engineering.

Keywords: Amination; Nanocrystalline cellulose; Optimization; Response surface modelling; Yield.

MeSH terms

Amination
Cellulose / chemistry*
Drug Delivery Systems / methods
Hydrogen-Ion Concentration
Nanoparticles / chemistry*
Tissue Engineering / methods

Substances

Cellulose
microcrystalline cellulose