Why validation of prognostic models matters?

Abstract

Prognostic models are powerful tools for treatment personalisation. However, not all proposed models work well when validated using new data, despite impressive results being reported initially. Here, we will use a hands-on approach to highlight important aspects of prognostic modelling, as well as to demonstrate methods to generate generalisable models.

Keywords: Biomarkers; Prognostic models; TRIPOD; Validation.