Abstract
The tumor suppressor p53 induces cell cycle arrest and/or apoptosis by transactivating numerous downstream target genes and also translocating to the mitochondrial outer membrane.
MeSH terms
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Amino Acid Substitution
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Animals
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Apoptosis / genetics*
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Cell Cycle Checkpoints / genetics*
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Gene Expression Regulation, Neoplastic*
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Humans
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Mutation, Missense*
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Neoplasms* / genetics
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Neoplasms* / metabolism
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Neoplasms* / pathology
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Tumor Suppressor Protein p53* / genetics
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Tumor Suppressor Protein p53* / metabolism
Substances
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TP53 protein, human
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Tumor Suppressor Protein p53