Modeling the Effect of Mucin Binding in the Gut on Drug Delivery

Bull Math Biol. 2019 Sep;81(9):3460-3476. doi: 10.1007/s11538-018-0417-3. Epub 2018 Mar 28.

Abstract

An important part the absorption, distribution, metabolism and excretion of an oral therapeutic is the flux rate of drug compound crossing the mucus lining of the gut. To understand this part of the absorption process, we develop a mathematical model of advection, diffusion and binding of drug compounds within the mucus layer of the intestines. Analysis of this model yields simple, measurable criteria for the successful mucin layer traversal of drug compound.

Keywords: ADME; Intestinal mucus layer; Mathematical model; Protein binding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computer Simulation
  • Drug Delivery Systems / methods
  • Drug Delivery Systems / statistics & numerical data
  • Drug Development / methods
  • Drug Development / statistics & numerical data
  • Humans
  • Intestinal Absorption
  • Intestinal Mucosa / metabolism*
  • Mathematical Concepts
  • Models, Biological*
  • Mucins / metabolism*
  • Nonlinear Dynamics
  • Pharmaceutical Preparations / administration & dosage*
  • Pharmacokinetics
  • Protein Binding

Substances

  • Mucins
  • Pharmaceutical Preparations