H2S to Mitigate Vascular Aging: A SIRT1 Connection

Thiruma V Arumugam; Brian K Kennedy

doi:10.1016/j.cell.2018.03.011

H₂S to Mitigate Vascular Aging: A SIRT1 Connection

Cell. 2018 Mar 22;173(1):8-10. doi: 10.1016/j.cell.2018.03.011.

Authors

Thiruma V Arumugam¹, Brian K Kennedy²

Affiliations

¹ Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117593, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
² Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117593, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, MD7, 8 Medical Drive, Singapore 117596, Singapore; Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: bkennedy@nus.edu.sg.

PMID: 29571000
DOI: 10.1016/j.cell.2018.03.011

Abstract

H₂S is an endogenous gasotransmitter that plays an important role in physiological conditions. In this issue, Das et al. provide evidence that SIRT1-dependent angiogenesis is augmented by H₂S-findings reinforced by Longchamp et al., who demonstrate that H₂S-dependent angiogenesis is triggered by amino acid deprivation.

Publication types

Comment

MeSH terms

NAD*
Sirtuin 1*

Substances

NAD
Sirtuin 1