New dihydrophenanthrenes from Dendrobium infundibulum

Nat Prod Res. 2019 Feb;33(3):420-426. doi: 10.1080/14786419.2018.1455050. Epub 2018 Mar 23.

Abstract

Two new dihydrophenanthrenes, dendroinfundin A (1) and dendroinfundin B (2) were isolated from the whole plant of Dendrobium infundibulum, together with 7 known compounds (3-9). The structures of the new compounds (1 and 2) were established on the basis of their spectroscopic data. All of the isolates were evaluated for their α-glucosidase and pancreatic lipase inhibitory activities. Batatasin III (5) and dendrosinen B (9) showed strong α-glucosidase inhibitory activity. Dendrosinen B (9) also exhibited appreciable pancreatic lipase inhibitory effect.

Keywords: dihydrophenanthrene; ochidaceae; pancreatic lipase; α-glucosidase.

MeSH terms

  • Dendrobium / chemistry*
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Glycoside Hydrolase Inhibitors / pharmacology
  • Lipase / antagonists & inhibitors
  • Molecular Structure
  • Phenanthrenes / chemistry
  • Phenanthrenes / isolation & purification*
  • Stilbenes / isolation & purification
  • Stilbenes / pharmacology
  • alpha-Glucosidases / drug effects

Substances

  • Glycoside Hydrolase Inhibitors
  • Phenanthrenes
  • Stilbenes
  • batatasin-III
  • Lipase
  • PNLIP protein, human
  • alpha-Glucosidases