Relationship between "a body shape index (ABSI)" and body composition in obese patients with type 2 diabetes

Fernando Gomez-Peralta; Cristina Abreu; Margarita Cruz-Bravo; Elvira Alcarria; Gala Gutierrez-Buey; Nir Y Krakauer; Jesse C Krakauer

doi:10.1186/s13098-018-0323-8

Relationship between "a body shape index (ABSI)" and body composition in obese patients with type 2 diabetes

Diabetol Metab Syndr. 2018 Mar 20:10:21. doi: 10.1186/s13098-018-0323-8. eCollection 2018.

Authors

Fernando Gomez-Peralta¹, Cristina Abreu¹, Margarita Cruz-Bravo¹, Elvira Alcarria¹, Gala Gutierrez-Buey¹, Nir Y Krakauer², Jesse C Krakauer³

Affiliations

¹ 1Segovia General Hospital, C/Miguel Servet s/n, 40002 Segovia, Spain.
² 2Department of Civil Engineering, The City College of New York, New York, NY USA.
³ Metro Detroit Diabetes and Endocrinology, Southfield, MI USA.

Abstract

Background: Obesity is known to be related to the development of type 2 diabetes mellitus (T2D). The most commonly used anthropometric indicator (body mass index [BMI]) presents several limitations such as the lack of possibility to distinguish adipose tissue distribution. Thus, this study examines the suitability of a body shape index (ABSI) for prediction of body composition and sarcopenic obesity in obese or overweight T2D subjects.

Methods: Cross-sectional study in 199 overweight/obese T2D adults. Anthropometric (BMI, ABSI) and body composition (fat mass [FM], fat-free mass [FFM], fat mass index [FMI] and fat-free mass index, and the ratio FM/FFM as an index of sarcopenic obesity) data was collected, as well as metabolic parameters (glycated haemoglobin [HbA_1c], mean blood glucose, fasting plasma glucose [FPG], high-density-lipoprotein cholesterol [HDL], low-density-lipoprotein cholesterol, total cholesterol, and triglycerides [TG] levels; the ratio TG/HDL was also calculated as a surrogate marker for insulin resistance).

Results: ABSI was significantly associated with age and waist circumference. It showed a statistically significant correlation with BMI exclusively in women. Regarding body composition, in men, ABSI was associated with FM (%), while in women it was associated with both FM and FFM. Both males and females groups with high ABSI scores were significantly older (men: 59.3 ± 10.8 vs 54.6 ± 10.1, p ≤ 0.05; women: 65.1 ± 9.8 vs 58.1 ± 13.3, p ≤ 0.005) and showed lower FFM values (men: 62.3 ± 9.0 vs 66.2 ± 9.3, p ≤ 0.05; women: 48.7 ± 5.6 vs 54.5 ± 8.9, p ≤ 0.001) compared with low-ABSI groups. Multiple linear regression revealed that ABSI independently predict FMI and the FM/FFM ratio in women. Sarcopenic obesity was identified in 70 (36.5%) individuals according to the FM/FFM ratio. The AUROC of ABSI was 63.1% (95% CI 54.6-71.6%; p = 0.003) and an ABSI value of 0.083 m^11/6 kg^-2/3 was the optimal threshold in discriminating patients with sarcopenic obesity (sensitivity: 48%, specificity: 73%). Moreover, a significant association between ABSI and FPG was found in men.

Conclusions: ABSI could be useful to identify visceral and sarcopenic obesity in overweight/obese adults with T2D, adding some relevant clinical information to traditional anthropometric measures.

Keywords: A body shape index; Body composition; Obesity; Sarcopenic obesity; Type 2 diabetes.