Data on the ecology of geohelminths and epizootiology of main geohelminthiases of Karakul sheep under conditions of desert-pasture biocoenoses of the Kyzyl Kum in the Bukhara and Navoi Provinces of the Uzbek SSR are given. 23 species of geohelminths belonging to 14 genera and 8 families are reported from this zone. Age and seasonal dynamics of the infection rate of Karakul sheep with geohelminths are established. Survival of eggs and larvae of some widely distributed geohelminths in central Kyzyl Kum is determined. On the basis of results of investigations recommendations on the control of main helminthiases of Karakul sheep in Bukhara and Navoi Provinces are worked out.