Artificial selection increased body weight but induced increase of runs of homozygosity in Hanwoo cattle

PLoS One. 2018 Mar 21;13(3):e0193701. doi: 10.1371/journal.pone.0193701. eCollection 2018.

Abstract

Artificial selection has been demonstrated to have a rapid and significant effect on the phenotype and genome of an organism. However, most previous studies on artificial selection have focused solely on genomic sequences modified by artificial selection or genomic sequences associated with a specific trait. In this study, we generated whole genome sequencing data of 126 cattle under artificial selection, and 24,973,862 single nucleotide variants to investigate the relationship among artificial selection, genomic sequences and trait. Using runs of homozygosity detected by the variants, we showed increase of inbreeding for decades, and at the same time demonstrated a little influence of recent inbreeding on body weight. Also, we could identify ~0.2 Mb runs of homozygosity segment which may be created by recent artificial selection. This approach may aid in development of genetic markers directly influenced by artificial selection, and provide insight into the process of artificial selection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight / genetics*
  • Cattle
  • Genome
  • Genomics
  • Genotype
  • Homozygote*
  • Inbreeding*
  • Male
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Selection, Genetic*

Grants and funding

This work was supported by a grant from the Next-Generation BioGreen 21 Program (Project No. PJ01323701), Rural Development Administration, Republic of Korea. The funder provided support in the form of salaries for authors KC, JJ and HK, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.