Multidimensional gas chromatography (MDGC) is well-established GC method used for a diverse range of applications. Enantioselective MDGC (enantio-MDGC) has been suggested as the method of preference for the separation of extremely overlapping enantiomers. An extensive number of literatures describe enantio-MDGC of polychlorinated biphenyls, essential oils and flavor and fragrance and amino acids were reported. In this review, the applications of MDGC approaches both, heart cutting GC-GC and comprehensive GC × GC in chiral analysis is presented. Since the application of these techniques in this filed is very broad so it will be divided into sections according to the type of the compounds.
Keywords: Amino acids; chiral analysis; essential oils; flavor and fragrance; multidimensional gas chromatography (MDGC); polychlorinated biphenyls (PCBs).