[Qualitative characterization of flavonoids in Scutellariae Radix by using PREC-IDA-EPI]

Yang Wei; Shu-Yao Wang; Si-Yang Wu; Chen Kang; Ying-Fei Li

doi:10.19540/j.cnki.cjcmm.20171027.004

[Qualitative characterization of flavonoids in Scutellariae Radix by using PREC-IDA-EPI]

Zhongguo Zhong Yao Za Zhi. 2018 Jan;43(2):345-352. doi: 10.19540/j.cnki.cjcmm.20171027.004.

[Article in Chinese]

Authors

Yang Wei¹, Shu-Yao Wang¹, Si-Yang Wu¹, Chen Kang¹, Ying-Fei Li¹

Affiliation

¹ Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

PMID: 29552854
DOI: 10.19540/j.cnki.cjcmm.20171027.004

Abstract

Flavonoids are the most abundant constituents and induce these the rapeutic effects against inflammation, gastrointestinal infections, cardiovascular diseases, and respiratory. Most of these flavonoids have low content in Scutellarie Radix. It was difficult to detect some minor compounds by using LC-MS method with full scan. Based on the review of flavonoids that had been extracted from Scutellariae Radix, a method with PREC-IDA-EPI technique was developed and applied to Scutellariae Radix by using UPLC-MS/MS. A total of 97 flavonoids were identified, including 29 aglycones and 68 O-glycosides. This study laid the foundation for pharmacodynamicss of Scutellariae Radix.It is believed that an individual detection scheme based on the PREC-IDA-EPI technique could be used to identify unknown compounds.

Keywords: LC-MS; PREC-IDA-EPI; Scutellariae Radix; flavonoids.

MeSH terms

Chromatography, Liquid
Drugs, Chinese Herbal / chemistry*
Flavonoids / isolation & purification*
Scutellaria baicalensis / chemistry*
Tandem Mass Spectrometry

Substances

Drugs, Chinese Herbal
Flavonoids