Neurophysiological Changes Measured Using Somatosensory Evoked Potentials

Antonella Macerollo; Matt J N Brown; James M Kilner; Robert Chen

doi:10.1016/j.tins.2018.02.007

Neurophysiological Changes Measured Using Somatosensory Evoked Potentials

Trends Neurosci. 2018 May;41(5):294-310. doi: 10.1016/j.tins.2018.02.007. Epub 2018 Mar 14.

Authors

Antonella Macerollo¹, Matt J N Brown², James M Kilner³, Robert Chen⁴

Affiliations

¹ Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK; These authors contributed equally to this work.
² Division of Brain, Imaging and Behavior - Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Kinesiology and Health Science, California State University Sacramento, Sacramento, CA, USA; These authors contributed equally to this work. Electronic address: matt.brown@csus.edu.
³ Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.
⁴ Division of Brain, Imaging and Behavior - Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, University of Toronto and Krembil Research Institute Toronto, Ontario, Canada.

PMID: 29549962
DOI: 10.1016/j.tins.2018.02.007

Abstract

Measurements of somatosensory evoked potentials (SEPs), recorded using electroencephalography during different phases of movement, have been fundamental in understanding the neurophysiological changes related to motor control. SEP recordings have also been used to investigate adaptive plasticity changes in somatosensory processing related to active and observational motor learning tasks. Combining noninvasive brain stimulation with SEP recordings and intracranial SEP depth recordings, including recordings from deep brain stimulation electrodes, has been critical in identifying neural areas involved in specific temporal stages of somatosensory processing. Consequently, this fundamental information has furthered our understanding of the maladaptive plasticity changes related to pathophysiology of diseases characterized by abnormal movements, such as Parkinson's disease, dystonia, and functional movement disorders.

Keywords: SEPs; brain stimulation; motor learning; movement disorders; oscillations; plasticity; sensorimotor integration.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / physiology*
Brain / physiopathology*
Evoked Potentials, Somatosensory*
Humans
Nervous System Diseases / diagnosis
Nervous System Diseases / physiopathology
Neurophysiological Monitoring

Abstract

Publication types

MeSH terms

Grants and funding