Antibody Phage Display

Abstract

Antibody phage display has become an indispensable tool for the discovery and optimization of target-specific monoclonal antibodies suitable for demanding applications including therapeutic reagents. The in vitro nature of the technology enables the rapid and efficient identification of specific binders, as well as greater control over selection parameters that facilitates the isolation of antibodies with unique, desirable functional characteristics. In this chapter, the technological background and the state of the art in the field of antibody phage display is discussed.

Keywords: Antibody library; Bacteriophage; Fab; Immune antibody library; Natural antibody library; Phage display; Synthetic antibody library; scFv.