Fungal Secretion: The Next-Gen Target of Antifungal Agents?

Julianne Teresa Djordjevic; Sophie Lev

doi:10.1016/j.chembiol.2018.02.015

Fungal Secretion: The Next-Gen Target of Antifungal Agents?

Cell Chem Biol. 2018 Mar 15;25(3):233-235. doi: 10.1016/j.chembiol.2018.02.015.

Authors

Julianne Teresa Djordjevic¹, Sophie Lev²

Affiliations

¹ Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, NSW 2145, Australia; Sydney Medical School - Westmead, University of Sydney, Westmead, NSW 2145, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia. Electronic address: julianne.djordjevic@sydney.edu.au.
² Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, NSW 2145, Australia; Sydney Medical School - Westmead, University of Sydney, Westmead, NSW 2145, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia.

PMID: 29547713
DOI: 10.1016/j.chembiol.2018.02.015

Abstract

Invasive fungal diseases pose a serious threat, and new drugs are urgently needed. In this issue of Cell Chemical Biology, Pries et al. (2018) identified benzamide- and picolinamide-based small-molecule inhibitors with antifungal properties, including some active against pathogenic Candida species. These compounds target an essential component of the fungal secretion machinery, suggesting a new approach to antifungal development.

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MeSH terms

Amides
Antifungal Agents*
Benzamides
Candida*
Picolinic Acids

Substances

Amides
Antifungal Agents
Benzamides
Picolinic Acids
picolinamide