Synthesis of (2 H)-Indazoles through Rh(III)-Catalyzed Annulation Reaction of Azobenzenes with Sulfoxonium Ylides

J Org Chem. 2018 Apr 6;83(7):4070-4077. doi: 10.1021/acs.joc.8b00501. Epub 2018 Mar 20.

Abstract

The rhodium(III)-catalyzed C-H functionalization followed by intramolecular annulation reactions between azobenzenes and sulfoxonium ylides is described. This protocol leads to the efficient formation of 3-acyl (2 H)-indazoles with a range of substrate scope. A high level of chemoselectivity and functional group tolerance of this transformation were also observed.

Publication types

  • Research Support, Non-U.S. Gov't