Methylglyoxal - a signaling molecule in plant abiotic stress responses

Abstract

Abiotic stresses are the most common harmful factors, adversely affecting all aspects of plants' life. Plants have to elicit appropriate responses against multifaceted effects of abiotic stresses by reprogramming various cellular processes. Signaling molecules play vital roles in sensing environmental stimuli to modulate gene expression, metabolism and physiological processes in plants to cope with the adverse effects. Methylglyoxal (MG), a dicarbonyl compound, is known to accumulate in cells as a byproduct of various metabolic pathways, including glycolysis. Several works in recent years have demonstrated that MG could play signaling roles via Ca²⁺, reactive oxygen species (ROS), K⁺ and abscisic acid. Recently, global gene expression profiling has shown that MG could induce signaling cascades, and an overlap between MG-responsive and stress-responsive signaling events might exist in plants. Once overaccumulated in cells, MG can provoke detrimental effects by generating ROS, forming advanced glycation end products and inactivating antioxidant systems. Plants are also equipped with MG-detoxifying glyoxalase system to save cellular organelles from MG toxicity. Since MG has regulatory functions in plant growth and development, and glyoxalase system is an integral component of abiotic stress adaptation, an in-depth understanding on MG metabolism and glyoxalase system will help decipher mechanisms underlying plant responses to abiotic stresses. Here, we provide a comprehensive update on the current knowledge of MG production and detoxification in plants, and highlight the putative functions of glyoxalase system in mediating plant defense against abiotic stresses. We particularly emphasize on the dual roles of MG and its connection with glutathione-related redox regulation, which is crucial for plant defense and adaptive responses under changing environmental conditions.

Keywords: Detoxification; Glyoxalase system; Methylglyoxal; Oxidative stress; Plant abiotic stress; Redox regulation; Signaling molecules.