Antibiotic Activity of Probiotic Strain Bacillus subtilis 534 Against Clinical Isolates of Acinetobacter baumannii

O V Efremenkova; N I Gabrielyan; I A Malanicheva; T A Efimenko; L P Terekhova; V V Udalova; A A Glukhova; E A Rogozhin; V A Alferova; V A Korshun; M Kh Kubanova; I V Drabkina; T V Krupenio

Antibiotic Activity of Probiotic Strain Bacillus subtilis 534 Against Clinical Isolates of Acinetobacter baumannii

Antibiot Khimioter. 2016;61(9-10):3-7.

[Article in English, Russian]

Authors

O V Efremenkova, N I Gabrielyan, I A Malanicheva, T A Efimenko, L P Terekhova, V V Udalova, A A Glukhova, E A Rogozhin, V A Alferova, V A Korshun, M Kh Kubanova, I V Drabkina, T V Krupenio

PMID: 29539244

Abstract

Probiotic strain Bacillus subtilis 534 is the base of sporobacterin, a pharmaceutical. In submerged culture it showed antibiotic activity against many of gram-positive and gram-negative bacteria and fungi. The spectrum of the antimicrobial activity of the culture fluid depended on the.cultivation time and aeration intensity. It was shown that component No. 1 of the antibiotic complex was effective against clinical isolates of Acinetobacter baumannii: 20 out of 24 isolates were susceptible to component No. 1, including 15 strains out of 16 panresistant isolates.