Abstract
In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.
MeSH terms
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Antineoplastic Agents / administration & dosage*
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Drug Delivery Systems*
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Galectins / metabolism
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Gold
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Hepatitis A Virus Cellular Receptor 2 / metabolism
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Humans
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Leukemia, Myeloid, Acute / drug therapy*
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Metal Nanoparticles
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Nanoconjugates*
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Single-Chain Antibodies / administration & dosage*
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THP-1 Cells
Substances
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Antineoplastic Agents
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Galectins
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HAVCR2 protein, human
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Hepatitis A Virus Cellular Receptor 2
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LGALS9 protein, human
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Nanoconjugates
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Single-Chain Antibodies
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Gold