1 Interdepartmental Division of Critical Care Medicine; and Institute of Health Policy, Management, & Evaluation, University of Toronto, Toronto, ON, Canada Interdepartmental Division of Critical Care Medicine, University of Toronto; Institute of Health Policy, Management, & Evaluation, University of Toronto;, Departments of Medicine and Physiology, University of Toronto; Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital; and Toronto General Research Institute, Toronto, ON, Canada.