Bortezomib plus EPOCH is effective as frontline treatment in patients with plasmablastic lymphoma

Br J Haematol. 2019 Feb;184(4):679-682. doi: 10.1111/bjh.15156. Epub 2018 Mar 12.

Authors

Jorge J Castillo¹, Thomas Guerrero-Garcia², Francesco Baldini³, Emmanuelle Tchernonog⁴, Guillaume Cartron⁴, Slavisa Ninkovic⁵, Kate Cwynarski⁵, Daan Dierickx⁶, Thomas Tousseyn⁶, Frederick Lansigan⁷, Yevgeny Linnik⁷, Renzo Mogollon⁸, Jose-Tomás Navarro⁹, Adam J Olszewski¹⁰, John L Reagan¹⁰, Pasquale Fedele¹¹, Michael Gilbertson¹¹, George Grigoriadis¹¹, Michele Bibas³

Affiliations

¹ Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
² Division of Hematology and Oncology, Dana-Farber Cancer Institute at St. Elizabeth's Medical Center, Brighton, MA, USA.
³ National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy.
⁴ Department of Haematology, CHU Montpellier, Montpellier, France.
⁵ Department of Haematology, UCLH London, London, UK.
⁶ Department of Haematology, University Hospitals Leuven, Leuven, Belgium.
⁷ Division of Hematology and Oncology, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH, USA.
⁸ Department of Medicine, Universidad San Martin de Porres, Lima, Peru.
⁹ Catalan Institute of Oncology, German Trias I Pujol Hospital, Badalona, Spain.
¹⁰ Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
¹¹ Monash Haematology, Monash Medical Centre, Monash University, Clayton, Australia.

PMID: 29527667
DOI: 10.1111/bjh.15156

No abstract available

Keywords: bortezomib; chemotherapy; plasmablastic lymphoma; survival.

Publication types

Clinical Trial
Letter
Multicenter Study

MeSH terms

Aged
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Bortezomib / administration & dosage*
Bortezomib / adverse effects
Cyclophosphamide / administration & dosage
Cyclophosphamide / adverse effects
Disease-Free Survival
Doxorubicin / administration & dosage
Doxorubicin / adverse effects
Etoposide / administration & dosage
Etoposide / adverse effects
Female
Humans
Male
Middle Aged
Plasmablastic Lymphoma / drug therapy*
Plasmablastic Lymphoma / mortality*
Plasmablastic Lymphoma / pathology
Prednisone / administration & dosage
Prednisone / adverse effects
Retrospective Studies
Survival Rate
Vincristine / administration & dosage
Vincristine / adverse effects

Substances

Vincristine
Bortezomib
Etoposide
Doxorubicin
Cyclophosphamide
Prednisone

Supplementary concepts

EPOCH protocol