To get a complete understanding of cell migration, it is critical to study its orchestration at the molecular level. Since the recent developments in single-molecule imaging, it is now possible to study molecular phenomena at the single-molecule level inside living cells. In this chapter, we describe how such approaches have been and can be used to decipher molecular mechanisms involved in cell migration.
Keywords: Cell migration; Integrin-dependent adhesion; Lamellipodium; Single-protein tracking; Superresolution microscopy.