The Cytokinin-Activating LOG-Family Proteins Are Not Lysine Decarboxylases

Muhammad Naseem; Elena Bencurova; Thomas Dandekar

doi:10.1016/j.tibs.2018.01.002

The Cytokinin-Activating LOG-Family Proteins Are Not Lysine Decarboxylases

Trends Biochem Sci. 2018 Apr;43(4):232-236. doi: 10.1016/j.tibs.2018.01.002. Epub 2018 Mar 7.

Authors

Muhammad Naseem¹, Elena Bencurova², Thomas Dandekar³

Affiliations

¹ Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany; Systems Biology of Plant-Microbes Interaction (SPI) Lab, Department of Molecular Biology and Genetics, Bogazici University, Kuzey Park, Istanbul, Turkey; College of Natural and Health Sciences, Department of Life and Environmental Sciences, Zayed University, Abu Dhabi, UAE; These authors have equally contributed to this work. Electronic address: muhammad.naseem@zu.ac.ae.
² Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany; These authors have equally contributed to this work.
³ Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany. Electronic address: dandekar@biozentrum.uni-wuerzburg.de.

PMID: 29525484
DOI: 10.1016/j.tibs.2018.01.002

Abstract

A conserved PGGxGTxxE motif misleads the cytokinin (CK) converting LONELY GUY enzymes to be wrongly annotated as lysine decarboxylases (LDCs). However, so far PGGxGTxxE motif-containing LDCs do not show any LDC activity. Instead, they show phosphoribohydrolase activity by converting inactive CK nucleotides into active free-base forms to invoke CK responses.

Keywords: LOG-family proteins; PGGxGTxxE motif; active cytokinins; cross-kingdom regulation; lysine decarboxylase; phosphoribohydrolase.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carboxy-Lyases* / metabolism
Cytokinins / metabolism*
Humans
Hydrolases / metabolism*

Substances

Cytokinins
Hydrolases
Carboxy-Lyases
lysine decarboxylase