In this paper, a novel framework for designing optimized photonic crystal (PhC) sensors has been proposed. The complexity of such structures has resulted in the lack of an analytical method to design the structures. Therefore, this framework aims to provide a comprehensive and automatic method to find the best values for the structural parameters without human involvement. The framework is explained with an example of designing a PhC liquid sensor. In the framework, an optimizer called the "multi-objective gray wolf optimizer" is utilized. However, a diverse range of multi-objective optimizer algorithms could be utilized. The results show that the proposed framework can design any kind of PhC sensor. Simplicity, being straightforward, and no human involvement are the advantages of the proposed framework. In addition, a significantly wide range of optimal designs will be found that are suitable for general and specific applications.