Design of artificial enzymes by supramolecular strategies

Tingting Wang; Xiaotong Fan; Chunxi Hou; Junqiu Liu

doi:10.1016/j.sbi.2018.02.003

Design of artificial enzymes by supramolecular strategies

Curr Opin Struct Biol. 2018 Aug:51:19-27. doi: 10.1016/j.sbi.2018.02.003. Epub 2018 Mar 6.

Authors

Tingting Wang¹, Xiaotong Fan¹, Chunxi Hou¹, Junqiu Liu²

Affiliations

¹ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China.
² State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: junqiuliu@jlu.edu.cn.

PMID: 29518619
DOI: 10.1016/j.sbi.2018.02.003

Abstract

Enzymes are biomacromolecules with three-dimensional structures composed of peptide polymers via supramolecular interactions. Owing to the incredible catalytic efficiency and unique substrate selectivity, enzymes arouse considerable attention. To rival natural enzymes, various artificial enzymes have been developed over the last decades. Since supramolecular interactions play important roles in both substrate recognition and the process of enzymatic catalysis, designing artificial enzymes using supramolecular strategies is undoubtedly significant. Here we discuss the recent advances in constructing artificial enzymes using supramolecular platforms.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Catalysis
Enzymes / chemistry*
Enzymes / metabolism*
Macromolecular Substances / chemistry*
Macromolecular Substances / metabolism*
Oxidation-Reduction
Protein Binding
Protein Engineering* / methods
Structure-Activity Relationship
Substrate Specificity

Substances

Enzymes
Macromolecular Substances