Functional Magnetic Resonance Imaging in Alzheimer' Disease Drug Development

Methods Mol Biol. 2018:1750:159-163. doi: 10.1007/978-1-4939-7704-8_10.

Abstract

While now commonly applied for studying human brain function the value of functional magnetic resonance imaging in drug development has only recently been recognized. Here we describe the different functional magnetic resonance imaging techniques applied in Alzheimer's disease drug development with their applications, implementation guidelines, and potential pitfalls.

Keywords: Alzheimer’s disease; Biomarker; Dementia; Prevention; Treatment; fMRI.

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / pathology
  • Animals
  • Brain / drug effects
  • Brain / pathology
  • Drug Development*
  • Humans
  • Magnetic Resonance Imaging / methods*