Modulating the rigidity of nanoparticles for tumor penetration

Hongzhang Deng; Kun Song; Jianhua Zhang; Liandong Deng; Anjie Dong; Zhihai Qin

doi:10.1039/c8cc00398j

Modulating the rigidity of nanoparticles for tumor penetration

Chem Commun (Camb). 2018 Mar 25;54(24):3014-3017. doi: 10.1039/c8cc00398j. Epub 2018 Mar 7.

Authors

Hongzhang Deng¹, Kun Song², Jianhua Zhang³, Liandong Deng³, Anjie Dong³, Zhihai Qin²

Affiliations

¹ The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. zhihai@ibp.ac.cn and Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. ajdong@tju.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China and Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
² The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. zhihai@ibp.ac.cn and Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
³ Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. ajdong@tju.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China.

PMID: 29511753
DOI: 10.1039/c8cc00398j

Abstract

How the rigidity of nanoparticles affects their penetration into tumors is unclear. Core-shell nanoparticles were prepared with amphipathic poly(ethylene glycol)-b-(poly ε-caprolactone-g-poly butyl acrylate) (PEG-(PCL-g-PBA)) so that the mechanical stiffness of their cores could be varied in order to test the relationship between their rigidity and penetration through tumors. The rigidity of the nanoparticles was adjusted by the changeable crystallinity of the core, which was altered by varying the ratio of ε-caprolactone and butyl acrylate.

MeSH terms

Animals
Cell Line, Tumor
Drug Carriers / chemistry*
Drug Carriers / metabolism*
Ethylene Glycols / chemistry
Ethylene Glycols / metabolism
Ethylene Glycols / pharmacokinetics
Mice
Nanoparticles / chemistry*
Nanoparticles / metabolism*
Neoplasms / metabolism*
Particle Size
Polyesters / chemistry
Polyesters / metabolism
Polyesters / pharmacokinetics
Surface-Active Agents / chemistry
Surface-Active Agents / metabolism
Surface-Active Agents / pharmacokinetics

Substances

Drug Carriers
Ethylene Glycols
Polyesters
Surface-Active Agents
poly(epsilon-caprolactone)-b-poly(ethylene glycol)