Presence of rare hepatitis C virus subtypes, 2j, 2k, and 2r in Mexico City as identified by sequencing

J Med Virol. 2018 Jul;90(7):1277-1282. doi: 10.1002/jmv.25070. Epub 2018 Apr 23.

Abstract

The HCV 5'UTR, Core/E1, and NS5B regions of samples from fifty patients infected with the hepatitis C virus (HCV) were analyzed. Seventeen patients were identified with genotype (GT) 1b, eleven with GT-1a, nine with GT-2b and four with GT-3a. Two rare subtypes were detected: GT-2j in two patients and GT-2r in one patient. Three patients had mixed infections: one with GT-2k + 2j and two with GT-1b + 2b. This work identifies HCV GTs, 2j, 2k, and 2r for the first time in Mexico.

Keywords: epidemiology; evolution; genetic variability; hepatitis C virus; virus classification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5' Untranslated Regions / genetics
  • Adult
  • Cities
  • Female
  • Genetic Variation*
  • Genotype*
  • Genotyping Techniques
  • Hepacivirus / classification*
  • Hepacivirus / genetics*
  • Hepacivirus / isolation & purification
  • Hepatitis C / virology*
  • Humans
  • Male
  • Mexico
  • Middle Aged
  • Sequence Analysis, DNA
  • Viral Core Proteins / genetics
  • Viral Envelope Proteins / genetics
  • Viral Nonstructural Proteins / genetics

Substances

  • 5' Untranslated Regions
  • E1 protein, Hepatitis C virus
  • Viral Core Proteins
  • Viral Envelope Proteins
  • Viral Nonstructural Proteins
  • nucleocapsid protein, Hepatitis C virus
  • NS-5 protein, hepatitis C virus