ATP (Adenosine triphosphate) is an important endogenous damage - associated molecular pattern (DAMP). P2X7R is an ATP-gated cation channel. ATP-P2X7R plays a vital role in the pathophysiology of many diseases because P2X7R is distributed on various immune cells. ATP-P2X7R signal transduction pathway has been implicated to participate in the body's immune defense against pathogens. This paper reviews the recent progress regarding ATP-P2X7R and its effects on parasitic diseases.
［摘要］ 三磷酸腺苷 (Adenosine triphosphate, ATP)是机体内一种重要的内源性损伤相关分子模式 (Damage-associated molecular pattern, DAMP)。嘌呤受体P2X7 (Purinergic receptor, P2X7R)是以ATP为配体的离子门控通道, 在多种疾病的病理生理过程中发挥着重要作用。因P2X7R 表达于多种免疫细胞表面, ATP-P2X7R信号转导途径成为机体对抗病原体的重要组成部分。本文主要就ATP-P2X7R信号通路及其在寄生虫感染中的作用和机制作一综述。 ［关键词］三磷酸腺苷; 嘌呤受体P2X7; 巨噬细胞; 树突状细胞; 促炎因子; 寄生虫病.
Keywords: Adenosine triphosphate; Dendritic cell; Macrophage; P2X₇R; Parasitic disease; Proinflammatory mediator.