Altered B-cell homeostasis underlies a wide range of pathologies, from cancers to autoimmunity and immunodeficiency. The molecular safeguards against those disorders, which also allow effective immune responses, are therefore particularly critical. Here, we review recent findings detailing the fine control of B-cell homeostasis, during B-cell development, maturation in the periphery and during activation and differentiation into antibody-producing cells.
Keywords: Autoimmunity; B cells; BAFF; homeostasis; humoral immunity; primary immunodeficiency disorders.
© 2018 Australasian Society for Immunology Inc.