Expression of aberrantly spliced oncogenic Ikaros isoforms coupled with clonal IKZF1 deletions and chimeric oncogenes in acute lymphoblastic leukemia

Blood Cells Mol Dis. 2018 Jul:71:29-38. doi: 10.1016/j.bcmd.2018.02.001. Epub 2018 Feb 23.

Authors

Volha Vshyukova¹, Alena Valochnik², Alexander Meleshko²

Affiliations

¹ Belarusian Research Center for Pediatric Oncology, Haematology and Immunology, 223053, Frunzenskaya str., 43, Minsk Region, Belarus. Electronic address: vshyukova@gmail.com.
² Belarusian Research Center for Pediatric Oncology, Haematology and Immunology, 223053, Frunzenskaya str., 43, Minsk Region, Belarus.

PMID: 29496375
DOI: 10.1016/j.bcmd.2018.02.001

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Alternative Splicing*
Biomarkers
Case-Control Studies
Child
Child, Preschool
Cytogenetic Analysis
Female
Gene Deletion*
Gene Expression Regulation, Leukemic*
Humans
Ikaros Transcription Factor / genetics*
Immunophenotyping
Infant
Infant, Newborn
Male
Oncogene Proteins, Fusion / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Young Adult

Substances

Biomarkers
IKZF1 protein, human
Oncogene Proteins, Fusion
Ikaros Transcription Factor