Preoperative detection of malignant liver tumors: Comparison of 3D-T2-weighted sequences with T2-weighted turbo spin-echo and single shot T2 at 1.5 T

Maxime Barat; Philippe Soyer; Raphael Dautry; Marc Pocard; Rea Lo-Dico; Haythem Najah; Clarisse Eveno; Christophe Cassinotto; Anthony Dohan

doi:10.1016/j.ejrad.2018.01.007

Preoperative detection of malignant liver tumors: Comparison of 3D-T2-weighted sequences with T2-weighted turbo spin-echo and single shot T2 at 1.5 T

Eur J Radiol. 2018 Mar:100:7-13. doi: 10.1016/j.ejrad.2018.01.007. Epub 2018 Jan 11.

Authors

Maxime Barat¹, Philippe Soyer², Raphael Dautry³, Marc Pocard⁴, Rea Lo-Dico⁵, Haythem Najah⁶, Clarisse Eveno⁷, Christophe Cassinotto⁸, Anthony Dohan⁹

Affiliations

¹ Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France; UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France. Electronic address: maxime.barat89@gmail.com.
² UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France; Department of Body and Interventional Imaging, Hôpital Cochin, AP-HP, 27 rue du faubourg St Jacques, 75014 Paris, France; Université Sorbonne-Paris Cité, Paris-Diderot, 10 rue de Verdun, 75010 Paris, France. Electronic address: philippe.soyer@aphp.fr.
³ Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: raphael.dautry@aphp.fr.
⁴ UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France; Université Sorbonne-Paris Cité, Paris-Diderot, 10 rue de Verdun, 75010 Paris, France; Department of Digestive and Oncologic Surgery, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: marc.pocard@aphp.fr.
⁵ Université Sorbonne-Paris Cité, Paris-Diderot, 10 rue de Verdun, 75010 Paris, France; Department of Digestive and Oncologic Surgery, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: rea.lo-dico@aphp.fr.
⁶ Université Sorbonne-Paris Cité, Paris-Diderot, 10 rue de Verdun, 75010 Paris, France; Department of Digestive and Oncologic Surgery, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: haythem.najah@gmail.com.
⁷ UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France; Université Sorbonne-Paris Cité, Paris-Diderot, 10 rue de Verdun, 75010 Paris, France; Department of Digestive and Oncologic Surgery, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Electronic address: clarisse.eveno@aphp.fr.
⁸ Department of Diagnostic and Interventional Imaging, Hôpîtal Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, 1 Avenue de Magellan, 33604 Pessac, France; INSERM U1053, Université Bordeaux, Bordeaux, France. Electronic address: christophe.cassinotto@chu-bordeaux.fr.
⁹ UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010 Paris, France; Department of Body and Interventional Imaging, Hôpital Cochin, AP-HP, 27 rue du faubourg St Jacques, 75014 Paris, France; Université Sorbonne-Paris Cité, Paris-Diderot, 10 rue de Verdun, 75010 Paris, France; McGill University Health Center, Department of Radiology, McGill University Health Center, 1650 Cedar Avenue, Rm C5 118, Montreal, QC, Canada. Electronic address: anthony.dohan@mail.mcgill.ca.

PMID: 29496082
DOI: 10.1016/j.ejrad.2018.01.007

Abstract

Purpose: To assess the performances of three-dimensional (3D)-T2-weighted sequences compared to standard T2-weighted turbo spin echo (T2-TSE), T2-half-Fourier acquisition single-shot turbo spin-echo (T2-HASTE), diffusion weighted imaging (DWI) and 3D-T1-weighted VIBE sequences in the preoperative detection of malignant liver tumors.

Methods: From 2012 to 2015, all patients of our institution undergoing magnetic resonance imaging (MRI) examination for suspected malignant liver tumors were prospectively included. Patients had contrast-enhanced 3D-T1-weighted, DWI, 3D-T2-SPACE, T2-HASTE and T2-TSE sequences. Imaging findings were compared with those obtained at follow-up, surgery and histopathological analysis. Sensitivities for the detection of malignant liver tumors were compared for each sequence using McNemar test. A subgroup analysis was conducted for HCCs. Image artifacts were analyzed and compared using Wilcoxon paired signed rank-test.

Results: Thirty-three patients were included: 13 patients had 40 hepatocellular carcinomas (HCC) and 20 had 54 liver metastases. 3D-T2-weighted sequences had a higher sensitivity than T2-weighted TSE sequences for the detection of malignant liver tumors (79.8% versus 68.1%; P < 0.001). The difference did not reach significance for HCC. T1-weighted VIBE and DWI had a higher sensitivity than T2-weighted sequences. 3D-T2-weighted-SPACE sequences showed significantly less artifacts than T2-weitghted TSE.

Conclusion: 3D-T2-weighted sequences show very promising performances for the detection of liver malignant tumors compared to T2-weighted TSE sequences.

Keywords: 3D-MRI sequences; 3D-T2-SPACE sequence; Diagnostic performances; Hepatocellular carcinoma; Liver malignant tumors; MRI technique.

Publication types

Comparative Study

MeSH terms

Adult
Aged
Aged, 80 and over
Artifacts
Carcinoma, Hepatocellular / diagnostic imaging*
Female
Humans
Imaging, Three-Dimensional / methods*
Liver / diagnostic imaging
Liver Neoplasms / diagnostic imaging*
Liver Neoplasms / secondary
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Preoperative Care / methods*
Prospective Studies
Reproducibility of Results