Role of the Aryl Hydrocarbon Receptor in Su5416/Hypoxia-induced Pulmonary Hypertension: A New Mechanism for an "Old" Model

Am J Respir Cell Mol Biol. 2018 Mar;58(3):279-281. doi: 10.1165/rcmb.2017-0359ED.
No abstract available

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Azo Compounds / pharmacology
  • Cell Hypoxia / drug effects*
  • Disease Models, Animal
  • Emphysema / chemically induced
  • Endothelial Cells / metabolism
  • Humans
  • Hypertension, Pulmonary / chemically induced*
  • Hypertension, Pulmonary / pathology
  • Indoles / pharmacology*
  • Mice
  • Protein Kinase Inhibitors / pharmacology*
  • Pyrazoles / pharmacology
  • Pyrroles / pharmacology*
  • Rats
  • Receptors, Aryl Hydrocarbon / metabolism*
  • Vascular Endothelial Growth Factor Receptor-1 / antagonists & inhibitors
  • Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors

Substances

  • 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide
  • Azo Compounds
  • Indoles
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Pyrroles
  • Receptors, Aryl Hydrocarbon
  • Semaxinib
  • KDR protein, human
  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Endothelial Growth Factor Receptor-2