Macdonald, B, O'Neill, J, Pollock, N, and Van Hooren, B. Single-leg Roman chair hold is more effective than the Nordic hamstring curl in improving hamstring strength-endurance in Gaelic footballers with previous hamstring injury. J Strength Cond Res 33(12): 3302-3308, 2019-Poor hamstring strength-endurance is a risk factor for hamstring injuries. This study investigated the effectiveness of the single-leg Roman hold and Nordic hamstring curl in improving hamstring strength-endurance. Twelve Gaelic footballers (mean ± SD age, height, and mass were 25.17 ± 3.46 years, 179.25 ± 5.88 cm, 85.75 ± 4.75 kg, respectively) with a history of hamstring injury were randomized into 2 groups that performed 6 weeks of either Nordic hamstring curl or single-leg Roman chair hold training. The single-leg hamstring bridge (SLHB) was measured before and after intervention. The Roman chair group showed a very likely moderate magnitude improvement on SLHB performance for both legs (23.7% for the previously injured leg [90% confidence interval 9.6-39.6%] and 16.9% for the noninjured leg [6.2-28.8%]). The Nordic curl group showed a likely trivial change in SLHB performance for the noninjured leg (-2.1% [-6.7 to 2.6%]) and an unclear, but possibly trivial change for the previously injured leg (0.3% [-5.6 to 6.6%]). The Roman chair group improved very likely more with a moderate magnitude in both the noninjured (19.5% [8.0-32.2%]) and the previously injured leg (23.3% [8.5-40.0%]) compared with the Nordic curl group. This study demonstrated that 6-week single-leg Roman chair training substantially improved SLHB performance, suggesting that it may be an efficacious strategy to mitigate hamstring (re-) injury risk. Conversely, 6-week Nordic curl training did not substantially improve SLHB performance, suggesting this may not be the intervention of choice for modifying this risk factor.