Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002

J Nat Prod. 2018 Apr 27;81(4):1045-1049. doi: 10.1021/acs.jnatprod.7b00673. Epub 2018 Feb 28.

Abstract

Three new indole diterpenes, penicilindoles A-C (1-3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC50 values of 5.5 and 1.5 μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Cell Line, Tumor
  • Crystallography, X-Ray
  • Cytotoxins / chemistry
  • Cytotoxins / pharmacology*
  • Diterpenes / chemistry
  • Diterpenes / pharmacology*
  • Eupenicillium / chemistry*
  • Fungi
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Indoles / chemistry
  • Indoles / pharmacology
  • Magnetic Resonance Spectroscopy / methods
  • Penicillium / chemistry
  • Rhizophoraceae / microbiology*

Substances

  • Anti-Bacterial Agents
  • Cytotoxins
  • Diterpenes
  • Indoles
  • indole