Abstract
Three new indole diterpenes, penicilindoles A-C (1-3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC50 values of 5.5 and 1.5 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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A549 Cells
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Cell Line, Tumor
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Crystallography, X-Ray
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Cytotoxins / chemistry
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Cytotoxins / pharmacology*
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Diterpenes / chemistry
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Diterpenes / pharmacology*
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Eupenicillium / chemistry*
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Fungi
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HeLa Cells
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Hep G2 Cells
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Humans
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Indoles / chemistry
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Indoles / pharmacology
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Magnetic Resonance Spectroscopy / methods
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Penicillium / chemistry
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Rhizophoraceae / microbiology*
Substances
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Anti-Bacterial Agents
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Cytotoxins
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Diterpenes
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Indoles
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indole