Intratumor spatial heterogeneity has been ignored in evaluating tumor therapeutic effect with conventional imaging methods. The voxel-based parametric response map (PRM) derived from CT or MRI may accurately, objectively and timely evaluate the tumor response to therapy, by comparing changes of the functional parameters before and after treatment. This approach may improve the imaging monitoring and the sensitivity of spatial resolution related to tumor changes after treatment. Thus, PRM may help to improve the treatment plan and prognosis evaluation for patients. This article reviews progress on CT/MRI PRM in precision evaluation of therapeutic response of cancer patients.
传统影像学方法在评估肿瘤疗效时忽略了肿瘤内部空间反应的异质性，而基于逐个体素分析的CT和磁共振参数反应图通过对比肿瘤治疗前与治疗后（中）的功能参数差异，能较及时、客观、准确地评价肿瘤对治疗的反应，提高了肿瘤治疗相关变化的影像监测及其空间分辨的敏感度，有助于患者治疗方案的改进和预后评估。本文主要对CT和磁共振参数反应图及其在肿瘤精准疗效评估中的研究进展进行综述。