Ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non-biased 6-exo aza-Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.
Keywords: N-heterocycles; aza-Heck reaction; cascade reactions; palladium.
© 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.