Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates

Angew Chem Int Ed Engl. 2018 Apr 23;57(18):5124-5128. doi: 10.1002/anie.201801109. Epub 2018 Mar 22.

Abstract

Ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non-biased 6-exo aza-Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

Keywords: N-heterocycles; aza-Heck reaction; cascade reactions; palladium.

Publication types

  • Research Support, Non-U.S. Gov't