Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis, part 2

Clemens Ager; Karl Unterkofler; Pawel Mochalski; Susanne Teschl; Gerald Teschl; Chris A Mayhew; Julian King

doi:10.1088/1752-7163/aab2b6

Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis, part 2

J Breath Res. 2018 Apr 4;12(3):036011. doi: 10.1088/1752-7163/aab2b6.

Authors

Clemens Ager¹, Karl Unterkofler, Pawel Mochalski, Susanne Teschl, Gerald Teschl, Chris A Mayhew, Julian King

Affiliation

¹ Breath Research Institute, University of Innsbruck, Rathausplatz 4, A-6850 Dornbirn, Austria. Univ.-Clinic for Anesthesia and Intensive Care, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, Austria.

PMID: 29488464
DOI: 10.1088/1752-7163/aab2b6

Abstract

In a recent paper (Unterkofler et al 2015 J. Breath Res. 9 036002) we presented a simple two compartment model which describes the influence of inhaled concentrations on exhaled breath concentrations for volatile organic compounds (VOCs) with small Henry constants. In this paper we extend this investigation concerning the influence of inhaled concentrations on exhaled breath concentrations for VOCs with higher Henry constants. To this end we extend our model with an additional compartment which takes into account the influence of the upper airways on exhaled breath VOC concentrations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breath Tests / methods*
Exhalation
Humans
Models, Biological*
Volatile Organic Compounds / analysis*

Substances

Volatile Organic Compounds