Wide-field absolute transverse blood flow velocity mapping in vessel centerline

Nanshou Wu; Lei Wang; Bifeng Zhu; Caizhong Guan; Mingyi Wang; Dingan Han; Haishu Tan; Yaguang Zeng

doi:10.1117/1.JBO.23.2.026008

Wide-field absolute transverse blood flow velocity mapping in vessel centerline

J Biomed Opt. 2018 Feb;23(2):1-7. doi: 10.1117/1.JBO.23.2.026008.

Authors

Nanshou Wu¹, Lei Wang¹, Bifeng Zhu¹, Caizhong Guan¹, Mingyi Wang¹, Dingan Han¹, Haishu Tan¹, Yaguang Zeng¹

Affiliation

¹ Foshan University, Department of Physics and Optoelectronic Engineering, Guangdong, China.

PMID: 29488364
DOI: 10.1117/1.JBO.23.2.026008

Abstract

We propose a wide-field absolute transverse blood flow velocity measurement method in vessel centerline based on absorption intensity fluctuation modulation effect. The difference between the light absorption capacities of red blood cells and background tissue under low-coherence illumination is utilized to realize the instantaneous and average wide-field optical angiography images. The absolute fuzzy connection algorithm is used for vessel centerline extraction from the average wide-field optical angiography. The absolute transverse velocity in the vessel centerline is then measured by a cross-correlation analysis according to instantaneous modulation depth signal. The proposed method promises to contribute to the treatment of diseases, such as those related to anemia or thrombosis.

Keywords: absolute transverse blood flow velocity; vessel centerline; wide-field.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Angiography / methods*
Animals
Blood Flow Velocity / physiology*
Chick Embryo
Equipment Design
Image Processing, Computer-Assisted / methods*
Optical Imaging / methods*