Alternative statistical methods and their application to research in intensive care setting

Abstract

In nested case-control studies, sampling of controls is usually done by density of incidence and pairing. With regard to the classic control cases studies, nested ones are more efficient, allow the calculation of the incidence of the disease and they have more internal validity due to the lower presence of bias. Competitive risks techniques can be used if we study different types of events and focus on the time and type of the first event. Recursive partitioning is a type of multivariate analysis whose purpose is the construction of classification algorithms, and it is especially useful when there are a large number of predictive variables with complex relationships with the event.

Keywords: Caso-control anidado; Competitive events; Diseño híbrido; Eventos competitivos; Hybrid design; Nested case-control; Particiones recursivas; Recursive partitions.