Human Gut Microbiota in Health and Alzheimer's Disease

J Alzheimers Dis. 2018;62(2):549-560. doi: 10.3233/JAD-170908.

Abstract

Gut microbiota plays a crucial role in human health and disease. The alterations in the composition of gut microbiota may cause the onset of certain human pathologies. One of these is Alzheimer's disease (AD). High-fat diets, administration of antibiotics, lack of probiotics and/or prebiotics in diet increase the risk of AD. On the other hand, modulation of the composition of gut microbiota may decrease the risk of AD and be able to slow down the progression of AD.

Keywords: Alzheimer’s disease; dysbiosis; gut microbiota; metabolic endotoxemia; physiology.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / microbiology*
  • Alzheimer Disease / physiopathology*
  • Diet, High-Fat / adverse effects
  • Dysbiosis / microbiology
  • Gastrointestinal Microbiome*
  • Gastrointestinal Tract / microbiology*
  • Gastrointestinal Tract / physiopathology
  • Humans
  • Risk Factors