The contribution of feedback loops between miRNAs, cytokines and growth factors to the pathogenesis of psoriasis

Exp Dermatol. 2018 Jun;27(6):603-610. doi: 10.1111/exd.13520. Epub 2018 Apr 10.

Abstract

The present review describes in detail the existent data regarding feedback loops between miRNAs and cytokines or growth factors in the psoriatic inflammation. We have chosen to describe the roles of miR-31, miR-21, miR-146a, miR-155, miR-197 and miR-99a in this process. This choice derives from the fact that among around 250 miRNAs being altered in the psoriatic lesion, the comprehensive functional role was described only in those detailed above. In addition, considering the molecular targets and the pathways, which may possibly be regulated by those miRNAs, it seems that they may be chosen as preferred targets for the therapy of psoriasis.

Keywords: Psoriasis; feedback loops; miRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cytokines / metabolism*
  • Feedback, Physiological*
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Interferon-gamma / metabolism
  • MicroRNAs / metabolism*
  • NF-kappa B / metabolism
  • Psoriasis / metabolism*
  • Receptor, IGF Type 1
  • Receptors, Interleukin / metabolism
  • Receptors, Interleukin-17 / metabolism
  • Receptors, Somatomedin / metabolism
  • Signal Transduction
  • Transforming Growth Factor beta / metabolism
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Cytokines
  • IGF1R protein, human
  • IL17RA protein, human
  • Intercellular Signaling Peptides and Proteins
  • MIRN155 microRNA, human
  • MIRN197 microRNA, human
  • MIRN21 microRNA, human
  • MIRN31 microRNA, human
  • MIRN99 microRNA, human
  • MicroRNAs
  • NF-kappa B
  • Receptors, Interleukin
  • Receptors, Interleukin-17
  • Receptors, Somatomedin
  • Transforming Growth Factor beta
  • Tumor Necrosis Factor-alpha
  • interleukin-22 receptor
  • Interferon-gamma
  • Receptor, IGF Type 1