Accuracy of Xpert Mtb/Rif Ultra for the Diagnosis of Pulmonary Tuberculosis in Children

Pediatr Infect Dis J. 2018 Oct;37(10):e261-e263. doi: 10.1097/INF.0000000000001960.

Abstract

We determined the accuracy of the new Xpert MTB/RIF Ultra assay for diagnosis of pulmonary tuberculosis in children, using banked-induced sputum. Sensitivity and specificity were 75.3% and 96.9%, respectively, compared with a culture result from the same specimen. Of those children with microbiologically confirmed tuberculosis (positive Xpert, Ultra or culture), Xpert detected 63.2%, Ultra 73.7% and culture 82.9%.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Colony Count, Microbial
  • Female
  • Humans
  • Male
  • Molecular Diagnostic Techniques / standards*
  • Mycobacterium tuberculosis / isolation & purification
  • Sensitivity and Specificity
  • South Africa
  • Sputum / microbiology*
  • Tuberculosis, Pulmonary / diagnosis*