First Report of an ST410 OXA-181 and CTX-M-15 Coproducing Escherichia coli Clone in Italy: A Whole-Genome Sequence Characterization

Microb Drug Resist. 2018 Oct;24(8):1207-1209. doi: 10.1089/mdr.2017.0366. Epub 2018 Feb 23.

Abstract

We investigated an Italian OXA-181-producing Escherichia coli clinical isolate (ECS1_14) by whole-genome sequencing. The strain coharbored blaCTX-M-15, blaCMY-2, and qnrS1 genes; it belonged to ST410(Achtman)/ST692(Pasteur) and phylogroup A. The blaOXA-181 gene was harbored on a plasmid highly similar (99% identity) to the pOXA181_EC14828 plasmid, recently reported in China.

Keywords: IncX3 plasmid; Italy; blaOXA-181.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification*
  • Escherichia coli Infections / metabolism*
  • Escherichia coli Proteins / genetics*
  • Humans
  • Italy
  • Male
  • Whole Genome Sequencing / methods
  • beta-Lactamases / genetics*

Substances

  • Escherichia coli Proteins
  • beta-lactamase CTX-M-15
  • beta-Lactamases
  • beta-lactamase OXA-181, E coli