Clinical experience with indigenous kit-based preparation of 68Ga-DOTATOC using commercial 68Ge/68Ga generator

Usha Pandey; Aruna Korde; Archana Mukherjee; Ajit Shinto; K K Kamaleswaran; Raghi P Jose; Naresh Gamre; Ashutosh Dash

doi:10.1016/j.apradiso.2018.02.002

Clinical experience with indigenous kit-based preparation of ⁶⁸Ga-DOTATOC using commercial ⁶⁸Ge/⁶⁸Ga generator

Appl Radiat Isot. 2018 Jun:136:59-64. doi: 10.1016/j.apradiso.2018.02.002. Epub 2018 Feb 10.

Authors

Usha Pandey¹, Aruna Korde², Archana Mukherjee¹, Ajit Shinto³, K K Kamaleswaran³, Raghi P Jose³, Naresh Gamre⁴, Ashutosh Dash¹

Affiliations

¹ Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC), Mumbai 400085, India; Homi Bhabha National Institute, Anushakti Nagar, Mumbai 400094, India.
² Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC), Mumbai 400085, India; Homi Bhabha National Institute, Anushakti Nagar, Mumbai 400094, India. Electronic address: akorde@barc.gov.in.
³ Department of Nuclear Medicine and PET/CT, Kovai Medical Centre & Hospital Limited, Coimbatore, Tamil Nadu, India.
⁴ Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC), Mumbai 400085, India.

PMID: 29471222
DOI: 10.1016/j.apradiso.2018.02.002

Abstract

Pharmaceutical grade DOTATOC kits compliant with all the quality control criteria were formulated and radiolabeled with ⁶⁸Ga in high yields. Comparison with module-based ⁶⁸Ga-DOTATOC established product equivalency. Clinical utility was evaluated in patients with histopathologically confirmed well-differentiated neuroendocrine tumors. Kit-based preparation of ⁶⁸Ga-DOTATOC could identify sites of primary and metastatic disease. PET/CT images of patients conformed to the established criteria for somatostatin imaging agents and clinical expectations. Results of this study emphasize the potential of kit-based ⁶⁸Ga-DOTATOC for PET imaging of neuroendocrine tumors.

Keywords: (68)Ga; (68)Ge/(68)Ga generator; DOTATOC kits; Neuroendocrine tumors; Somatostatin.