Urinary myeloperoxidase to creatinine ratio as a new marker for monitoring treatment effects of urinary tract infection

Abstract

Objective: We want to determine whether urinary myeloperoxidase to creatinine ratio could be served as a new marker for monitoring treatment effects of urinary tract infection or not.

Methods: A total of 328 patients suspected of UTI were enrolled in present study. Patients been received antibiotic therapy within two weeks were excluded (n = 26). Patients with urine contaminated specimens (n = 49) and negative urine culture results (n = 96) were also excluded, the remaining culture positive subjects (n = 157) were followed up for 7 to 14 days, finally, a total of 49 subjects were followed up and further divided into cure (n = 35) and none-cure (n = 14) subgroups according to urine culture results. MPO concentration was determined by immunoturbidimetric method and creatinine level was measured by creatinine enzyme method. Two sided P values < 0.05 were considered statistically significant.

Results: Urinary MCR level between before and after antibiotic treatment of cure group were (1437.1 ± 1777.9 vs.48.3 ± 59.3, t = 4.608, P = 0.001), respectively. Urinary MCR level between before and after antibiotic treatment of none-cure group were (1633.1 ± 2168.7 vs. 999.4 ± 1708.0, t = 1.809, P = 0.094), respectively.

Conclusions: Urinary MCR could be served as a promising marker for monitoring treatment effects of urinary tract infection.

Keywords: Myeloperoxidase; Treatment effect; Urinary tract infection.