Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Alain S Leutou; Inho Yang; Tu Cam Le; Dongyup Hahn; Kyung-Min Lim; Sang-Jip Nam; William Fenical

doi:10.1038/s41429-018-0033-3

Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

J Antibiot (Tokyo). 2018 Jun;71(6):609-612. doi: 10.1038/s41429-018-0033-3. Epub 2018 Feb 21.

Authors

Alain S Leutou¹, Inho Yang¹, Tu Cam Le¹, Dongyup Hahn^{2

3}, Kyung-Min Lim⁴, Sang-Jip Nam⁵, William Fenical⁶

Affiliations

¹ Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Korea.
² School of Food and Biotechnology, Kyungpook National University, Daegu, Korea.
³ Institute of Agricultural Science & Technology, Kyungpook National University, Daegu, Korea.
⁴ College of Pharmacy, Ewha Womans University, Seoul, Korea. kmlim@ewha.ac.kr.
⁵ Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Korea. sjnam@ewha.ac.kr.
⁶ Center for marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, USA. wfenical@ucsd.edu.

PMID: 29467379
DOI: 10.1038/s41429-018-0033-3

Abstract

A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

MeSH terms

Actinomycetales / chemistry
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology*
Chromatography, High Pressure Liquid
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Lactams / chemistry
Lactams, Macrocyclic / chemistry
Lactams, Macrocyclic / isolation & purification*
Lactams, Macrocyclic / pharmacology*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Spectrophotometry, Ultraviolet

Substances

Anti-Bacterial Agents
Lactams
Lactams, Macrocyclic