Journal Club: MRI reveals acute inflammation in cortical lesions during early MS

Emily M Bateman; Wolfgang E Schleicher; Elana J Smith; David R Sweet; Andrew D Gaudet

doi:10.1212/WNL.0000000000005001

Journal Club: MRI reveals acute inflammation in cortical lesions during early MS

Neurology. 2018 Feb 20;90(8):e724-e726. doi: 10.1212/WNL.0000000000005001.

Authors

Emily M Bateman¹, Wolfgang E Schleicher¹, Elana J Smith¹, David R Sweet¹, Andrew D Gaudet²

Affiliations

¹ From the Department of Psychology and Neuroscience (E.M.B., W.E.S., E.J.S., A.D.G.), University of Colorado Boulder; and Medical Scientist Training Program (D.R.S.), Department of Pathology, Case Western Reserve University, Cleveland, OH.
² From the Department of Psychology and Neuroscience (E.M.B., W.E.S., E.J.S., A.D.G.), University of Colorado Boulder; and Medical Scientist Training Program (D.R.S.), Department of Pathology, Case Western Reserve University, Cleveland, OH. andrew.gaudet@colorado.edu.

Abstract

Early multiple sclerosis is characterized by immune-associated demyelination of CNS axons. In a recent Neurology® article, Maranzano et al. evaluated MRI scans of patients with early multiple sclerosis to study the evolution of leukocortical lesions. Their novel data suggest that acute inflammation after blood-brain barrier leakage may contribute to gray matter cortical lesions in early multiple sclerosis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Demyelinating Diseases*
Gray Matter
Humans
Inflammation
Magnetic Resonance Imaging
Multiple Sclerosis*