Clinical and Angiographic Predictors of Mortality in Sudden Cardiac Arrest Patients Having Cardiac Catheterisation: A Single Centre Registry

James Xu; Leia Hee; Andrew Hopkins; Craig P Juergens; Sidney Lo; John K French; Christian J Mussap

doi:10.1016/j.hlc.2018.01.005

Clinical and Angiographic Predictors of Mortality in Sudden Cardiac Arrest Patients Having Cardiac Catheterisation: A Single Centre Registry

Heart Lung Circ. 2019 Mar;28(3):370-378. doi: 10.1016/j.hlc.2018.01.005. Epub 2018 Feb 8.

Authors

James Xu¹, Leia Hee¹, Andrew Hopkins¹, Craig P Juergens¹, Sidney Lo¹, John K French¹, Christian J Mussap²

Affiliations

¹ Cardiology Department, Liverpool Hospital, Sydney, NSW, Australia; South Western Sydney Clinical School, The University of NSW, Sydney, NSW, Australia.
² Cardiology Department, Liverpool Hospital, Sydney, NSW, Australia; South Western Sydney Clinical School, The University of NSW, Sydney, NSW, Australia. Electronic address: Christian.Mussap@health.nsw.gov.au.

PMID: 29459218
DOI: 10.1016/j.hlc.2018.01.005

Abstract

Background: Immediate cardiac catheterisation (CC) is recommended in ST-elevation myocardial infarction (STEMI) following sudden cardiac arrest (SCA). Guidelines advise urgent CC for SCA patients without-STEMI, at clinician discretion. We examined the clinical and angiographic factors predicting mortality in SCA patients having CC.

Methods: Consecutive SCA patients having CC at Liverpool Hospital, Sydney (January 2011-September 2015) were retrospectively analysed. Patient data were retrieved from hospital records, and angiographic SYNTAX scores (SS) were quantified online. Independent predictors of mortality were derived using multivariate logistic analysis.

Results: The study cohort comprised 104 SCA patients; mean age 61±12years, and 79% male. Immediate CC (<2hours post-SCA) was performed in 35% overall. Compared to the without-STEMI subgroup, STEMI patients had more ventricular fibrillation (91 vs 50%; p<0.0001), and higher mean peak serum high-sensitivity troponin-T (8.25±14.7 vs 1.97±6.13 ug/L; p=0.006); in the context of higher median SS (18 vs 6.5; p=0.002) and target-lesion SS (tSS, 10 vs 0; p<0.001). Percutaneous coronary intervention (PCI; 75 vs 23%; p<0.0001) and target vessel revascularisation (11 vs 0%; p=0.005) were more frequent for STEMI. All-cause mortality was 39%, at 1.3±1.5years follow-up. Independent mortality predictors were: delayed CC (HR 4.08), serum lactate >7mmol/L (HR 3.47), and tSS (HR 1.05).

Conclusions: Elevated serum lactate, tSS, and delayed CC, were predictive of longer-term mortality in SCA patients having CC. Late CC in patients without-STEMI suggest scope for improvement in real-world systems of care. Closer scrutiny of target lesion complexity may aid prognostication in SCA survivors.

Keywords: PCI: Percutaneous coronary intervention; SCA: Sudden cardiac arrest; STEMI: ST-elevation myocardial infarction.

MeSH terms

Cardiac Catheterization / adverse effects*
Coronary Angiography / methods*
Death, Sudden, Cardiac / epidemiology
Death, Sudden, Cardiac / etiology*
Female
Follow-Up Studies
Hospital Mortality
Humans
Male
Middle Aged
New South Wales / epidemiology
Percutaneous Coronary Intervention
Predictive Value of Tests
Registries*
Retrospective Studies
Risk Factors
ST Elevation Myocardial Infarction / diagnosis*
ST Elevation Myocardial Infarction / mortality
ST Elevation Myocardial Infarction / surgery
Survival Rate / trends
Time Factors