Development of Protein-Protein Interaction Inhibitors for the Treatment of Infectious Diseases

Adv Protein Chem Struct Biol. 2018:111:197-222. doi: 10.1016/bs.apcsb.2017.07.005. Epub 2017 Aug 24.

Abstract

Protein-protein interaction (PPI) inhibitors are a rapidly expanding class of therapeutics. Recent advances in our understanding of PPIs and success of early examples of PPI inhibitors demonstrate the feasibility of targeting PPIs. This review summarizes the techniques used for the discovery and optimization of a diverse set PPI inhibitors, focusing on the development of PPI inhibitors as new antibacterial and antiviral agents. We close with a summary of the advances responsible for making PPI inhibitors realistic targets for therapeutic intervention and brief outlook of the field.

Keywords: Antibiotic resistance; Antibiotics; Antiviral; Drug discovery; Protein–protein interactions; Small-molecule inhibitors.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Bacteria / drug effects
  • Communicable Diseases / drug therapy*
  • Communicable Diseases / microbiology
  • Communicable Diseases / virology
  • HIV Fusion Inhibitors / chemistry
  • HIV Fusion Inhibitors / pharmacology*
  • HIV Integrase Inhibitors / chemistry
  • HIV Integrase Inhibitors / pharmacology*
  • Host Microbial Interactions / drug effects
  • Human Immunodeficiency Virus Proteins / antagonists & inhibitors*
  • Human Immunodeficiency Virus Proteins / metabolism
  • Humans

Substances

  • Anti-Bacterial Agents
  • Antiviral Agents
  • HIV Fusion Inhibitors
  • HIV Integrase Inhibitors
  • Human Immunodeficiency Virus Proteins