The role of human papillomavirus vaccines in cervical cancer: Prevention and treatment

Crit Rev Oncol Hematol. 2018 Feb:122:92-97. doi: 10.1016/j.critrevonc.2017.12.017. Epub 2017 Dec 28.

Abstract

Human papillomavirus (HPV) is the most common sexually transmitted disease, worldwide. Primary prevention thorough vaccination si able to reduce the burden of HPV-related lesions. Ten years ago the Food and drug Administration (FDA) approved the first vaccine against HPV. In the last decades, growing data on safety and effectiveness have been collected. In the present review we report the current knowledge on vaccine against HPV, highlighting the current value and prospective regarding the widespread diffusion of HPV vaccines. The role of emerging therapeutic vaccines is reviewed.

Keywords: Cervical cancer; HPV; Therapeutic vaccine; Vaccine.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Papillomaviridae / immunology
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Vaccines / administration & dosage*
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Uterine Cervical Neoplasms / prevention & control
  • Uterine Cervical Neoplasms / therapy*
  • Uterine Cervical Neoplasms / virology*
  • Vaccination / statistics & numerical data

Substances

  • Papillomavirus Vaccines